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In vivo experiments exhibit anatomically selective neurochemical consequences of modafinil on monoaminergic devices (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, whilst modafinil boosts TMN fos expression (Scammell et al 2000) and HAergic tone it's not able to exert this effect when administered straight in to the TMN (Ishizuka e

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